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Methods Enzymol. 2009;459:17-47. doi: 10.1016/S0076-6879(09)04602-3.

Structural enzymology of polyketide synthases.

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  • 1Department of Molecular Biology, University of California, Irvine, California, USA.


This chapter describes structural and associated enzymological studies of polyketide synthases, including isolated single domains and multidomain fragments. The sequence-structure-function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. Structural enzymology sheds light on sequence and structural motifs that are important for the precise timing, substrate recognition, enzyme catalysis, and protein-protein interactions leading to the extraordinary structural diversity of naturally occurring polyketides.

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