[Colchicine intoxication in four elderly patients: how to prevent it?]

Rev Med Interne. 2009 Sep;30(9):783-8. doi: 10.1016/j.revmed.2009.03.013. Epub 2009 Apr 10.
[Article in French]

Abstract

Introduction: In France, unlike other countries, the use of colchicine is preferred to other anti-inflammatory drugs for the treatment of gout.

Case reports: We report a case series of four elderly patients (range from 72 to 83 years of age) who presented with colchicine intoxication, all notified to the Basse-Normandie pharmacovigilance centre in 2007. For each patient, one or more risk factors were identified: renal failure, high initial dosage, absence of laboratory monitoring.

Conclusion: It would be useful to establish specific guidelines for colchicine use in the elderly population.

Publication types

  • Case Reports
  • Comparative Study
  • English Abstract

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Colchicine / administration & dosage
  • Colchicine / poisoning*
  • Female
  • France
  • Gout / drug therapy*
  • Gout Suppressants / administration & dosage
  • Gout Suppressants / poisoning*
  • Humans
  • Male
  • Poisoning / prevention & control
  • Polypharmacy
  • Product Surveillance, Postmarketing
  • Risk Factors

Substances

  • Gout Suppressants
  • Colchicine