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    Nature. 2009 Apr 9;458(7239):719-24. doi: 10.1038/nature07943.

    The cancer genome.

    Stratton MR, Campbell PJ, Futreal PA.

    Source

    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. mrs@sanger.ac.uk

    Abstract

    All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

    PMID:
    19360079
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2821689
    Free PMC Article

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