Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
J Med Genet. 2009 Jul;46(7):451-4. doi: 10.1136/jmg.2008.064956. Epub 2009 Apr 8.

A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.

Author information

  • 1Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Abstract

BACKGROUND:

Telomere length is a predictor for a number of common age related diseases and is a heritable trait.

METHODS AND RESULTS:

To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314,075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6 x 10(-6); and rs7235755, p = 5.5 x 10(-6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast.

CONCLUSION:

These results provide new insights into the pathways regulating telomere homeostasis in humans.

PMID:
19359265
[PubMed - indexed for MEDLINE]
PMCID:
PMC2696823
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk