Send to:

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2009 May;30(5):209-17. doi: 10.1016/ Epub 2009 Apr 7.

The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions.

Author information

  • 1Mater Medical Research Institute, Aubigny Place, Brisbane, QLD 4101, Australia.


The CD300 glycoproteins are a family of cell surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. Family members share a common evolutionary pathway and at least one member of the family has undergone significant positive selection, indicating their crucial value to the host. This review clarifies the occasionally confusing usage of nomenclature for the CD300 family and summarizes our current understanding of their genomics, expression and function. Their ability to fine tune leukocyte function and immune responses highlights several potential options to exploit the CD300 molecules as therapeutic targets in chronic inflammatory diseases, allergy and other disease states.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk