Bioorg Med Chem Lett. 2009 May 1;19(9):2396-9. Epub 2009 Mar 24.

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

Kumar TS, Ostergaard ME, Sharma PK, Nielsen P, Wengel J, Hrdlicka PJ.

Source

Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark.

Abstract

A short synthetic route to the first beta-l-ribo configured locked nucleic acid (LNA), that is, 2'-amino-beta-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2'-amino-beta-l-LNA thymine monomers into alpha-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

PMID:: 19356930; [PubMed - indexed for MEDLINE]

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