Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 2009 Jun 10;612(1-3):48-53. doi: 10.1016/j.ejphar.2009.03.070. Epub 2009 Apr 5.

Home seeking behavior in rat pups: Attachment vs. kin selection, oxytocin vs. vasopressin.

Author information

  • 1Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands. hein.sigling@brijder.nl

Abstract

We are interested in the rat as an animal model for infant-mother attachment. In the first experiment we tried to distinguish between a preference for familiar animals (attachment theory) and a preference for genetically related animals (kin selection theory) with the use of an early cross-fostering procedure. Genetic relationships did not influence preferences in cross-fostered pups on postnatal day 17, only familiarity did. Subsequently we investigated if peptides known to influence affiliative behaviors were also effective in the present paradigm. Injection of oxytocin into the cisterna magna did not yield significant effects on preference, while vasopressin and desglycinamide-[Arg8]vasopressin reduced the preference in a dose dependent manner. The effect of vasopressin was completely blocked by pretreatment with the vasopressin V(1A) receptor antagonist d(CH2)5Tyr(Me)(2),Arg(8)-vasopressin. We discuss the explanatory power of attachment theory and kin selection theory with regard to preference experiments in rats and the usefulness of the rat as an animal model for infant-mother attachment.

PMID:
19356730
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk