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    Drug Metab Lett. 2008 Apr;2(2):138-45.

    Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats.

    Wergedahl H, Berge K, Bohov P, Tronstad KJ, Madsen L, Berge RK.

    Source

    Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital, Bergen, Norway. hege.wergedahl@med.uib.no

    Abstract

    Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

    PMID:
    19356083
    [PubMed - indexed for MEDLINE]

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