Drug Metab Lett. 2007 Jan;1(1):17-21.

Comparison of paraben stability in human and rat skin.

Harville HM, Voorman R, Prusakiewicz JJ.

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Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA.

Abstract

Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

PMID:: 19356013; [PubMed - indexed for MEDLINE]

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