Iridium catalysis for C-H bond arylation of heteroarenes with iodoarenes

Angew Chem Int Ed Engl. 2009;48(20):3644-7. doi: 10.1002/anie.200806358.

Abstract

Efficient couplings using equimolar quantities of each coupling partner and multiple C-H bond arylation reactions are achieved with an Ir-based catalytic system for the C-H bond arylation of electron-rich heteroarenes with iodoarenes to construct extended pi-systems. The dramatic ligand effect on reaction efficiency leads to the discovery that Crabtree's catalyst (see scheme) is the optimal catalyst precursor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry*
  • Carbon / chemistry
  • Catalysis
  • Hydrogen Bonding
  • Iodine / chemistry
  • Iridium / chemistry*

Substances

  • Biological Products
  • Iridium
  • Carbon
  • Iodine