Chem Biodivers. 2009 Apr;6(4):527-39.

Nonenzymatic, self-elimination degradation mechanism of glutathione.

Deshmukh M, Kutscher H, Stein S, Sinko P.

Source

Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA.

Abstract

In the present in vitro studies, evidence is provided showing that glutathione (GSH) can undergo spontaneous, nonenzymatic auto-degradation. The initial cleavage of the Glu-Cys bond involves nucleophilic attack of the N-terminal amino group of GSH at the gamma-carbonyl side chain, followed by an unusual cleavage of the Cys-Gly amide bond that is complete within 3-5 weeks in the physiological pH range. These observations may be useful for the development of novel biodegradable polymers and releasable prodrugs for sustained and targeted drug delivery applications.

PMID:: 19353534; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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MeSH Terms

Substances

Glutathione

Grant Support

U54AR055073/AR/NIAMS NIH HHS/United States

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