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    Fitoterapia. 2009 Jul;80(5):297-300. doi: 10.1016/j.fitote.2009.03.008. Epub 2009 Apr 5.

    Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae).

    Menichini F, Tundis R, Loizzo MR, Bonesi M, Marrelli M, Statti GA, Menichini F, Conforti F.

    Source

    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy.

    Abstract

    Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC(50) values of 227.5 and 362.1 microg/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC(50) values of 134.7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml).

    PMID:
    19351555
    [PubMed - indexed for MEDLINE]

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