Display Settings:

Format

Send to:

Choose Destination
Angew Chem Int Ed Engl. 2009;48(19):3482-5. doi: 10.1002/anie.200900112.

One-pot, direct incorporation of [11C]CO2 into carbamates.

Author information

  • 1Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. hooker@bnl.gov

Abstract

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

Comment in

PMID:
19350593
[PubMed - indexed for MEDLINE]
PMCID:
PMC2757932
Free PMC Article

Images from this publication.See all images (2)Free text

Scheme 1
Scheme 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk