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Neuroreport. 2009 May 6;20(7):657-62.

Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells.

Kidambi S, Yarmush J, Fong W, Kamath S, Schianodicola J, Nahmias Y.

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Department of Anesthesiology, New York Methodist Hospital, Brooklyn, New York, USA.

Abstract

This study explored the effects of propofol on c-Fos and Egr-1 in neuroblastoma (N2A) cells. We demonstrate that propofol induced the expression of c-Fos and Egr-1 within 30 and 60 min of exposure time. At 16.8 microM concentration, propofol induced a 6 and 2.5-fold expression of c-Fos and Egr-1, respectively. However, at concentrations above 100 microM, propofol failed to induce expression of c-Fos or Egr-1. Propofol-induced c-Fos and Egr-1 transcription was unaffected by bicuculline, a gamma-aminobutyric acid-A receptor antagonist, but was abolished by PD98059, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor. Our study shows that clinically relevant concentrations of propofol induce c-Fos and Egr-1 expression through an extracellular signal-regulated kinase mediated and gamma-aminobutyric acid-A independent pathway.

PMID:: 19349923; [PubMed - indexed for MEDLINE]
PMCID: PMC2801809

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Cited by 1 PubMed Central article

Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices. [BMC Res Notes. 2010]
Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices.
Kidambi S, Yarmush J, Berdichevsky Y, Kamath S, Fong W, Schianodicola J. BMC Res Notes. 2010 Jul 17; 3:201. Epub 2010 Jul 17.

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