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Nihon Rinsho. 2009 Apr;67(4):742-9.

[Roles of angiotensin II receptor blockers in stroke prevention].

[Article in Japanese]

Author information

  • Department of Neurology, Saitama International Medical Center, Saitama Medical University.

Abstract

Strict blood pressure control is critical for stroke prevention. However, recent basic studies have shown that angiotensin II receptor blockers (ARBs) can protect the brain through mechanisms, such as antioxidant action, improved endothelial cell function and cerebral vessel remodeling, by inhibiting the effects of sympathetic nervous activity and by maintaining cerebral blood flow or blood brain barrier function. Moreover, ARBs reduce the likelihood of new onset of diabetes mellitus and atrial fibrillation. Several clinical trials including the JIKEI HEART Study, MOSES and ACCESS have revealed that ARBs help to prevent stroke via other pathways in addition to lowering blood pressure.

PMID:
19348237
[PubMed - indexed for MEDLINE]
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