Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endokrynol Pol. 2008 Nov-Dec;59(6):496-501.

The role of growth hormone and insulin-like growth factor I in oxidative processes.

Author information

  • 1Zakład Endokrynologii Onkologicznej, Katedra Endokrynologii i Chorób Metabolicznych, Uniwersytet Medyczny, Łódź.

Abstract

Under physiological conditions, there is a balance between the production and detoxification of reactive oxygen species (ROS). In the course of several diseases, an overproduction of ROS and their increased reaction with biological macromolecules, lead to disruption of this balance and to enhanced oxidative stress. Alterations in growth hormone (GH)/insulin-like growth factor I (IGF-I) pathway (e.g., in condition of GH overproduction or deficiency) are tightly linked with enhanced oxidative stress. The results of experimental and clinical studies, in which effects of GH and IGF-I on oxidative processes were revealed, are presented in the survey.

PMID:
19347815
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Via Medica Medical Publishers
    Loading ...
    Write to the Help Desk