Ann Epidemiol. 2009 Apr;19(4):250-2.

The search for protection against HIV infection.

Source

School of Public Health, Department of Epidemiology, University of California-Los Angeles, 650 Charles Young Drive, Los Angeles, CA 90085-1772, USA. detels@ucla.edu

Abstract

More than 25 years after the recognition of AIDS and the isolation of the causative agent, human immunodeficiency virus (HIV), we have been unable to develop a vaccine to protect against infection. The major obstacle to development of a vaccine has been the absence of naturally acquired protective immunity, which is characteristic of most infectious agents. We and others, however, have identified individuals who appear to be resistant to infection. Using a combination of epidemiology, molecular biology, and genetics, we hypothesize that these individuals are able to resist infection by clearing low doses of HIV from their systems. We further hypothesize that they are able to clear the virus through a highly efficient system of processing and presentation of HIV epitopes (antigens) to CD8+ cytotoxic cells, which activate them to remove virally infected cells. Subsequent studies have lent support to this hypothesis.

PMID:: 19344863; [PubMed - indexed for MEDLINE]
PMCID: PMC2767230

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model. [Vaccine. 2001]
Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model.
Nehete PN, Chitta S, Hossain MM, Hill L, Bernacky BJ, Baze W, Arlinghaus RB, Sastry KJ. Vaccine. 2001 Dec 12; 20(5-6):813-25.
Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. [J Exp Med. 1997]
Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization.
Tobery TW, Siliciano RF. J Exp Med. 1997 Mar 3; 185(5):909-20.
Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy. [J Immunol. 2007]
Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy.
Yang H, Dong T, Turnbull E, Ranasinghe S, Ondondo B, Goonetilleke N, Winstone N, di Gleria K, Bowness P, Conlon C, et al. J Immunol. 2007 Jul 1; 179(1):597-606.
Review The prospects for vaccines against HIV-1: more than a field of long-term nonprogression? [Expert Rev Mol Med. 2005]
Review The prospects for vaccines against HIV-1: more than a field of long-term nonprogression?
Sheppard N, Sattentau Q. Expert Rev Mol Med. 2005 Feb 8; 7(2):1-21. Epub 2005 Feb 8.
Review Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS. [Immunol Today. 1999]
Review Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS.
Shearer GM, Pinto LA, Clerici M. Immunol Today. 1999 Feb; 20(2):66-71.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

The search for protection against HIV infection.
The search for protection against HIV infection.
Ann Epidemiol. 2009 Apr ;19(4):250-2.

PubMed
Pharmacy workers' sexually transmitted diseases/human immunodeficiency virus kno...
Pharmacy workers' sexually transmitted diseases/human immunodeficiency virus knowledge in Fuzhou, China: implications for human immunodeficiency virus testing, treatment, and prevention strategies.
Sex Transm Dis. 2009 Apr ;36(4):221-6.

PubMed
Demographic and behavioral factors associated with HIV testing in China.
Demographic and behavioral factors associated with HIV testing in China.
J Acquir Immune Defic Syndr. 2009 Apr 1 ;50(4):432-4.

PubMed
Identifying trait clusters by linkage profiles: application in genetical genomic...
Identifying trait clusters by linkage profiles: application in genetical genomics.
Bioinformatics. 2008 Apr 1 ;24(7):958-64. Epub 2008 Feb 29 .

PubMed
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgeh...
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways.
Genes Dev. 1999 Mar 1 ;13(5):505-10.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: