Format

Send to:

Choose Destination
See comment in PubMed Commons below
Lancet Oncol. 2009 May;10(5):475-80. doi: 10.1016/S1470-2045(09)70079-8. Epub 2009 Apr 1.

The surgical learning curve for laparoscopic radical prostatectomy: a retrospective cohort study.

Author information

  • 1Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. vickersa@mskcc.org

Abstract

BACKGROUND:

We previously reported the learning curve for open radical prostatectomy, reporting large decreases in recurrence rates with increasing surgeon experience. Here we aim to characterise the learning curve for laparoscopic radical prostatectomy.

METHODS:

We did a retrospective cohort study of 4702 patients with prostate cancer treated laparoscopically by one of 29 surgeons from seven institutions in Europe and North America between January, 1998, and June, 2007. Multivariable models were used to assess the association between surgeon experience at the time of each patient's operation and prostate-cancer recurrence, with adjustment for established predictors.

FINDINGS:

After adjusting for case mix, greater surgeon experience was associated with a lower risk of recurrence (p=0.0053). The 5-year risk of recurrence decreased from 17% to 16% to 9% for a patient treated by a surgeon with 10, 250, and 750 prior laparoscopic procedures, respectively (risk difference between 10 and 750 procedures 8.0%, 95% CI 4.4-12.0). The learning curve for laparoscopic radical prostatectomy was slower than the previously reported learning curve for open surgery (p<0.001). Surgeons with previous experience of open radical prostatectomy had significantly poorer results than those whose first operation was laparoscopic (risk difference 12.3%, 95% CI 8.8-15.7).

INTERPRETATION:

Increasing surgical experience is associated with substantial reductions in cancer recurrence after laparoscopic radical prostatectomy, but improvements in outcome seem to accrue more slowly than for open surgery. Laparoscopic radical prostatectomy seems to involve skills that do not translate well from open radical prostatectomy.

FUNDING:

National Cancer Institute, the Allbritton Fund, and the David J Koch Foundation.

Comment in

PMID:
19342300
[PubMed - indexed for MEDLINE]
PMCID:
PMC2777762
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk