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Cell Stem Cell. 2009 Apr 3;4(4):277-8. doi: 10.1016/j.stem.2009.03.008.

Cardiovascular regeneration: pushing and pulling on progenitors.

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  • 1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115-6110, USA.


In this issue of Cell Stem Cell, Zaruba et al. (2009) describe a pharmacoregenerative strategy for myocardial infarction. Using G-CSF to release progenitors from bone marrow and protease inhibition to prevent degradation of the homing signal, SDF-1, the authors achieve increased recruitment to the heart and improved heart function.

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