Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genome Med. 2009 Mar 11;1(3):31. doi: 10.1186/gm31.

Narrowing down the role of common variants in the genetic predisposition to obesity.

Author information

  • 1Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

Abstract

The extent to which common variants contribute to common phenotypes and disease in humans has important consequences for the future of medical genomics. Two reports have recently clarified this issue for one of the most pressing public health concerns, obesity. These large and comprehensive genome-wide association studies find that common variants within at least 11 genes are associated with obesity. Interestingly, most of these genes are highly expressed in the central nervous system, further highlighting its role in the pathogenesis of obesity. However, the individual and combined effects of these variants explain only a small fraction of the inherited variability in obesity, suggesting that rare variants may contribute significantly to the genetic predisposition for this condition.

PMID:
19341502
[PubMed]
PMCID:
PMC2664942
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk