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J Neurophysiol. 2009 Jun;101(6):2872-7. doi: 10.1152/jn.91060.2008. Epub 2009 Apr 1.

Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy.

Author information

  • 1Centre for Functional Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom. cstagg@fmrib.ox.ac.uk

Erratum in

  • J Neurophysiol. 2011 Jun;105(6):3114.

Abstract

Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that causes significant inhibition of synaptic transmission for <or=1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this inhibition by noninvasively measuring local changes in the cortical concentrations of gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS to the left M1 led to an increase in GABA compared with stimulation at a control site without significant change in Glx. This direct evidence for increased GABAergic interneuronal activity is framed in terms of a new hypothesis regarding mechanisms underlying cTBS.

PMID:
19339458
[PubMed - indexed for MEDLINE]
PMCID:
PMC2694115
Free PMC Article

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