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Biochem Biophys Res Commun. 2009 Mar 20;380(4):721-3. doi: 10.1016/j.bbrc.2009.01.139. Epub 2009 Jan 27.

Cathepsin K: a therapeutic target for bone diseases.

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  • 1College of Chemical Engineering, Northeast Dianli University, Jilin, PR China.


Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.

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