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Nat Rev Genet. 2009 May;10(5):285-90. doi: 10.1038/nrg2571.

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.

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  • 1Oklahoma Medical Research Foundation, 825 North East 13th Street, Oklahoma City, Oklahoma 73104, USA.


Genome-wide association studies and fine mapping of candidate regions have rapidly advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE). More than 20 robust associations have now been identified and confirmed, providing insights at the molecular level that refine our understanding of the involvement of host immune response processes. In addition, genes with unknown roles in SLE pathophysiology have been identified. These findings may provide new routes towards improved clinical management of this complex disease.

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