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Expert Opin Ther Targets. 2009 Apr;13(4):443-54. doi: 10.1517/14728220902719233 .

PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma?

Author information

  • 1Miles and Shirley Fiterman Center for Digestive Diseases College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. roberts.lewis@mayo.edu

Abstract

BACKGROUND:

Hepatocellular carcinoma (HCC) develops most often in a background of chronic inflammatory liver injury from viral infection or alcohol use. Most HCCs are diagnosed at a stage at which surgical resection is not feasible. Even in patients receiving surgery rates of recurrence and metastasis remain high. There are few effective HCC therapies and hence a need for novel, rational approaches to treatment. Platelet derived growth factor receptor-alpha (PDGFR-alpha) is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of HCC.

OBJECTIVE:

To examine PDGFR-alpha as a target for therapy of HCC and explore opportunities and strategies for PDGFR-alpha inhibition.

METHODS:

A review of relevant literature.

RESULTS/CONCLUSIONS:

Targeted inhibition of PDGFR-alpha is a rational strategy for prevention and therapy of HCC.

[PubMed - indexed for MEDLINE]
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