Dysport: pharmacological properties and factors that influence toxin action

Toxicon. 2009 Oct;54(5):683-9. doi: 10.1016/j.toxicon.2009.03.020. Epub 2009 Mar 28.

Abstract

The pharmacological properties of Dysport that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered.

Publication types

  • Review

MeSH terms

  • Bacterial Toxins / chemistry
  • Bacterial Toxins / pharmacokinetics
  • Bacterial Toxins / pharmacology
  • Botulinum Toxins, Type A / chemistry
  • Botulinum Toxins, Type A / pharmacokinetics*
  • Botulinum Toxins, Type A / pharmacology
  • Diffusion*
  • Neuromuscular Agents / chemistry
  • Neuromuscular Agents / pharmacokinetics*
  • Neuromuscular Agents / pharmacology
  • Protein Conformation*
  • Structure-Activity Relationship

Substances

  • Bacterial Toxins
  • Neuromuscular Agents
  • Botulinum Toxins, Type A