Bone Marrow Transplant. 1991 Aug;8(2):143-5.

Successful treatment of disseminated Fusarium infection after autologous bone marrow transplantation for acute myeloid leukemia.

Robertson MJ, Socinski MA, Soiffer RJ, Finberg RW, Wilson C, Anderson KC, Bosserman L, Sang DN, Salkin IF, Ritz J.

Source

Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.

Abstract

Disseminated Fusarium is a rare but life-threatening infection of severely immunocompromised patients. A fatal outcome has been described in all reported cases of Fusarium infection occurring after bone marrow transplantation. We describe a patient who developed disseminated Fusarium infection with a secondary fungal endophthalmitis after an autologous bone marrow transplant for acute myeloid leukemia. This infection was successfully eradicated after neutrophil recovery by prolonged systemic administration of amphotericin B as well as aggressive local therapy including enucleation of the affected eye. The patient remains free of both leukemia and fungal disease more than 4 years after transplant.

PMID:: 1933056; [PubMed - indexed for MEDLINE]

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Amphotericin B

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CA 34183/CA/NCI NIH HHS/United States

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Cited by 4 PubMed Central articles

Disseminated fusariosis and endogenous fungal endophthalmitis in acute lymphoblastic leukemia following platelet transfusion possibly due to transfusion-related immunomodulation. [BMC Ophthalmol. 2011]
Disseminated fusariosis and endogenous fungal endophthalmitis in acute lymphoblastic leukemia following platelet transfusion possibly due to transfusion-related immunomodulation.
Kah TA, Yong KC, Rahman RA. BMC Ophthalmol. 2011 Nov 2; 11:30. Epub 2011 Nov 2.
Endophthalmitis caused by Fusarium proliferatum. [J Clin Microbiol. 2005]
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Disseminated hyalohyphomycosis caused by a novel human pathogen, Fusarium napiforme. [J Clin Microbiol. 1993]
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