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Int J Mol Sci. 2008 Dec;9(12):2424-46. Epub 2008 Dec 3.

Discovery of proteomic code with mRNA assisted protein folding.

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Homulus Foundation, Los Angeles, 90017 CA, USA. jan.biro@att.net

Abstract

The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding.

PMID:: 19330085; [PubMed]
PMCID:: PMC2635648

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