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Nat Genet. 2009 May;41(5):521-3. doi: 10.1038/ng.349. Epub 2009 Mar 29.

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

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  • 1Wellcome Trust Sanger Institute, Hinxton, UK.

Abstract

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.

PMID:
19330029
[PubMed - indexed for MEDLINE]
PMCID:
PMC2873835
Free PMC Article

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