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    Nat Genet. 2009 May;41(5):518-20. Epub 2009 Mar 29.

    Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

    Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y.

    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

    A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

    PMID: 19330028 [PubMed - indexed for MEDLINE]

    PMCID: 2748394

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