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Appl Environ Microbiol. 2009 Jun;75(11):3800-2. doi: 10.1128/AEM.00341-09. Epub 2009 Mar 27.

Translocation of a thioether-bridged azurin peptide fragment via the sec pathway in Lactococcus lactis.

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  • 1BiOMaDe Technology Foundation, Nijenborgh, AG Groningen, The Netherlands.


This study demonstrates for the first time that a thioether-containing peptide, an azurin fragment, can be translocated via the Sec pathway. This methyl-lanthionine was introduced by the nisin modification enzymes. The Sec pathway can therefore be a successful alternative for those cyclized peptides that are inefficiently transported via NisT.

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