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Neurobiol Aging. 2011 Feb;32(2):336-43. doi: 10.1016/j.neurobiolaging.2009.02.017. Epub 2009 Mar 28.

Cholesterol and serotonin transporter polymorphism interactions in late-life depression.

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  • 1Department of Psychiatry and Depression Clinical Research Center, Chonnam National University Medical School, Kwangju 501-757, Republic of Korea.

Abstract

BACKGROUND:

It has been suggested that the functional polymorphism in the serotonin transporter gene linked promoter region (5-HTTLPR) modifies associations between vascular diseases (coronary artery syndrome or stroke) and depression. This study investigated whether the 5-HTTLPR polymorphism has modifying effects on previously identified associations between cholesterol levels and prevalence/incidence of late-life depression.

METHODS:

In 732 community residents aged 65+, depression was ascertained (Geriatric Mental State Schedule) at baseline and after 2 years. 5-HTTLPR genotype and lipid levels (total, HDL and LDL cholesterol and triglycerides) were assayed. Covariates were age, sex, education, disability, and cognitive function.

RESULTS:

Significant associations between lower baseline HDL cholesterol levels with prevalent and incident depression were also modified by 5-HTTLPR polymorphism, and were only significant in the presence of one or more copies of the s allele.

CONCLUSION:

A more atherogenic lipid profile, as indicated by lower HDL cholesterol is a risk factor for late-life depression and this risk is modified by a gene implicated in serotonin transport.

Copyright © 2009 Elsevier Inc. All rights reserved.

PMID:
19329228
[PubMed - indexed for MEDLINE]
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