Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2009 May;19(5):218-27. doi: 10.1016/j.tcb.2009.02.004. Epub 2009 Mar 28.

Spine microdomains for postsynaptic signaling and plasticity.

Author information

  • 1Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Changes in the molecular composition and signaling properties of excitatory glutamatergic synapses onto dendritic spines mediate learning-related plasticity in the mammalian brain. This molecular adaptation serves as the most celebrated cell biological model for learning and memory. Within their micron-sized dimensions, dendritic spines restrict the diffusion of signaling molecules and spatially confine the activation of signal transduction pathways. Much of this local regulation occurs by spatial compartmentalization of glutamate receptors. Here, we review recently identified cell biological mechanisms regulating glutamate receptor mobility within individual dendritic spines. We discuss the emerging functions of glutamate receptors residing within sub-spine microdomains and propose a model for distinct signaling platforms with specialized functions in synaptic plasticity.

PMID:
19328694
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk