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Mol Imaging Biol. 2009 Sep-Oct;11(5):303-7. doi: 10.1007/s11307-009-0209-0. Epub 2009 Mar 27.

Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation.

Author information

  • 1Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655-0243, USA. guozheng.liu@umassmed.edu

Abstract

PURPOSE:

To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel.

PROCEDURES:

After receiving either 99mTc (MAG3)-cMORF or 111In (DTPA)-cMORF, normal mice were imaged and killed for pharmacokinetics. Thereafter, tumored mice were pretargeted withMORF-antibody, 48 h later were given an injection of 99mTc- or 111In-cMORF, and finally were imaged repeatedly.

RESULTS:

The cMORF biodistribution in both normal and pretargeted tumored mice was influenced by its radiolabel. While excretion of both 99mTc-cMORF and 111In-cMORF was rapid and mainly through the kidneys, about 2% of 99mTc accumulated in the intestines compared toessentially no intestinal accumulation for 111In at any time. Tumor accumulation was unchanged.

CONCLUSION:

In applications of MORF/cMORF pretargeting intended to image organs deep within the abdomen such as the pancreas, radiolabeling with 111In may be superior to 99mTc.

PMID:
19326173
[PubMed - indexed for MEDLINE]
PMCID:
PMC2720424
Free PMC Article
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