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Neuropsychobiology. 2009;59(2):96-9. doi: 10.1159/000209861. Epub 2009 Mar 27.

Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.

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  • 1Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea.


The 5-HT1Dbeta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dbeta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dbeta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dbeta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects.

2009 S. Karger AG, Basel.

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