J Pharm Biomed Anal. 1991;9(5):401-7.

Analysis of flucytosine dosage forms by derivative UV spectroscopy and liquid chromatography.

Source

Department of Pharmaceutical Sciences, University of Bologna, Italy.

Abstract

A simple second-order derivative spectrophotometric method was developed for the selective determination of flucytosine (an antimycotic drug) in the presence of 5-fluorouracil (a cytotoxic agent), its synthetic precursor and degradation product. Traces of 5-fluorouracil in flucytosine were also determined by derivative UV spectroscopy; flucytosine was removed by a selective solid-phase extraction (SPE) procedure using a strong cation-exchange sorbent. The spectrophotometric methods were applied successfully to the quality control of commercial dosage forms of flucytosine and the results were compared with those obtained by a HPLC procedure (cyano column) developed as a reference method.

PMID:: 1932275; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Analysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC). [J Pharm Biomed Anal. 1989]
Analysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC).
Cavrini V, Di Pietra AM, Gatti R. J Pharm Biomed Anal. 1989; 7(12):1535-43.
Determination of minoxidil in pharmaceutical formulations by difference spectrophotometry and liquid chromatography (HPLC). [Farmaco. 1990]
Determination of minoxidil in pharmaceutical formulations by difference spectrophotometry and liquid chromatography (HPLC).
Bonazzi D, Di Pietra AM, Gatti R, Cavrini V. Farmaco. 1990 Jun; 45(6 Suppl):727-35.
Determination of 5-fluorouracil in 5-fluorocytosine by high-performance thin-layer chromatography and derivative UV-spectrophotometry. [Pharm Acta Helv. 1988]
Determination of 5-fluorouracil in 5-fluorocytosine by high-performance thin-layer chromatography and derivative UV-spectrophotometry.
Quaglia MG, Carlucci G, Maurizi G, Mazzeo P. Pharm Acta Helv. 1988; 63(12):347-9.
An accelerated stability study of 5-flucytosine in intravenous solution. [Pharm World Sci. 1999]
An accelerated stability study of 5-flucytosine in intravenous solution.
Vermes A, van der Sijs H, Guchelaar HJ. Pharm World Sci. 1999 Feb; 21(1):35-9.
Review Interest of fluorine-19 nuclear magnetic resonance spectroscopy in the detection, identification and quantification of metabolites of anticancer and antifungal fluoropyrimidine drugs in human biofluids. [Chemotherapy. 2006]
Review Interest of fluorine-19 nuclear magnetic resonance spectroscopy in the detection, identification and quantification of metabolites of anticancer and antifungal fluoropyrimidine drugs in human biofluids.
Martino R, Gilard V, Desmoulin F, Malet-Martino M. Chemotherapy. 2006; 52(5):215-9. Epub 2006 Jul 25.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Analysis of flucytosine dosage forms by derivative UV spectroscopy and liquid ch...
Analysis of flucytosine dosage forms by derivative UV spectroscopy and liquid chromatography.
J Pharm Biomed Anal. 1991 ;9(5):401-7.

PubMed
Purification and partial amino acid sequence analysis of the larval settlement-i...
Purification and partial amino acid sequence analysis of the larval settlement-inducing pheromone from adult extracts of the barnacle, Balanus amphitrite (=Amphibalanus amphitrite).
Biofouling. 2009 ;25(5):429-34.

PubMed
Nested Ty3-gypsy retrotransposons of a single Beta procumbens centromere contain...
Nested Ty3-gypsy retrotransposons of a single Beta procumbens centromere contain a putative chromodomain.
Chromosome Res. 2009 ;17(3):379-96. Epub 2009 Mar 26 .

PubMed
Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL...
Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL?
Int J Hematol. 2009 May ;89(4):533-7. Epub 2009 Mar 26 .

PubMed
Discourse on the development of EEG diagnostics and biofeedback for attention-de...
Discourse on the development of EEG diagnostics and biofeedback for attention-deficit/hyperactivity disorders.
Biofeedback Self Regul. 1991 Sep ;16(3):201-25.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: