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Plast Reconstr Surg. 2009 Mar;123(3):790-3. doi: 10.1097/PRS.0b013e318199edeb.

Breast implants and lymphoma risk: a review of the epidemiologic evidence through 2008.

Author information

  • 1International Epidemiology Institute, Rockville, MD 20850, USA. loren@iei.us

Abstract

BACKGROUND:

In the past, concerns about lymphoma among women with breast implants have been raised by anecdotal observations. A recent report of a case-control study from The Netherlands reported an association of breast implants with anaplastic large T-cell lymphoma, but limitations inherent in the study design and the restriction of the association to saline implants preclude any causal evaluation.

METHODS:

To determine whether lymphoma risk is in fact elevated in women with breast implants, the authors have reviewed the evidence from five long-term follow-up studies comprising over 43,000 women with cosmetic breast implants followed for up to 37 years, which reported results specifically regarding the incidence of non-Hodgkin's lymphoma, among other cancers.

RESULTS:

Overall, there were 48 observed incident cases of non-Hodgkin's lymphoma compared with 53.9 cases expected, yielding a summary standardized incidence ratio of 0.89 (95 percent confidence interval, 0.67 to 1.18). None of the epidemiologic cohort studies reported a primary lymphoma originating in the breast.

CONCLUSIONS:

To date, there is no credible evidence of an increase of non-Hodgkin's lymphoma regardless of site or specifically originating in the breast among women with cosmetic breast implants.

PMID:
19319041
[PubMed - indexed for MEDLINE]
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