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    Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1298-303. Epub 2009 Mar 19.

    SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL.

    de Beer MC, Webb NR, Whitaker NL, Wroblewski JM, Jahangiri A, van der Westhuyzen DR, de Beer FC.

    Source

    Graduate Center for Nutritional Science, University of Kentucky Medical Center, Lexington, USA. mdebeer@uky.edu

    Abstract

    OBJECTIVE:

    The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL).

    METHODS AND RESULTS:

    We used SAA and SR-BI adenoviral vector expression models to study the interaction between these entities. SR-BI processing of mouse AP HDL generated progressively smaller discreet HDL particles with distinct apolipoprotein compositions. SR-BI actions segregated apolipoproteins with the smallest particles containing only apoA-I. Larger remnants contained apoA-I, apoA-II, and SAA. Small apoA-I only particles failed to associate with preformed HDL, whereas larger remnants readily did. The presence of SAA on SR-BI-processed HDL particles propelled apoA-I to a small lipid-poor form and accelerated apoA-I catabolism.

    CONCLUSIONS:

    Data indicate that after core and surface HDL lipid perturbation by SR-BI, SAA propels apoA-I to a small lipid-poor form while accelerating HDL metabolism.

    PMID:
    19304574
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2754709
    Free PMC Article

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