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Phytochemistry. 2009 Mar;70(5):675-83. doi: 10.1016/j.phytochem.2009.02.006. Epub 2009 Mar 19.

Pregnane glycosides from Hoodia gordonii.

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  • 1Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, USA.


Hoodia gordonii is a 'weight loss' herb, which has gained popularity in the western countries as an appetite suppressant dietary supplement. Phytochemical study of its aerial parts led to isolation of seven pregnane glycosides (hoodigosides W-Z, hoodistanalosides A-B). Their structures were elucidated by chemical degradation studies and spectroscopic methods, including 1D and 2D NMR and CD spectroscopic methods.

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