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Anesth Analg. 2009 Apr;108(4):1152-6. doi: 10.1213/ane.0b013e31819a6cf0.

The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial.

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  • 1Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark. ig@dadlnet.dk



In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort.


One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured.


Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups.


Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

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  • All results count. [Anesth Analg. 2009]
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