Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Pharmacol. 2009 Jun;75(6):1249-61. doi: 10.1124/mol.108.053140. Epub 2009 Mar 19.

Targeting protein serine/threonine phosphatases for drug development.

Author information

  • 1Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6600, USA.

Abstract

With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular signaling for therapeutic benefits. In this review, we present protein serine/threonine phosphatases as viable therapeutic targets, discussing past successes, current challenges, and future strategies for modulating phosphatase activity.

PMID:
19299564
[PubMed - indexed for MEDLINE]
PMCID:
PMC2684880
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk