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Am J Health Syst Pharm. 2009 Apr 1;66(7):665-7. doi: 10.2146/ajhp080152.

Stability of extemporaneously prepared moxifloxacin oral suspensions.

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  • 1Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY, USA.

Abstract

PURPOSE:

The stability of extemporaneously prepared moxifloxacin oral suspensions was studied.

METHODS:

An oral suspension of moxifloxacin 20 mg/mL was prepared by thoroughly grinding three 400-mg tablets of moxifloxacin in a glass mortar. Thirty milliliters of Ora-Plus and 30 mL of either Ora-Sweet or Ora-Sweet SF were mixed and added to the powder to make a final volume of 60 mL. Three identical samples of each formulation were prepared and placed in 2-oz amber plastic bottles with child-resistant caps and were stored at room temperature (23-25 degrees C). A 1-mL sample was withdrawn from each of the six bottles with a micropipette immediately after preparation and at 7, 14, 28, 60, and 90 days. After further dilution to an expected concentration of 8 microg/ mL with sample diluent, the samples were assayed in duplicate by stability-indicating high-performance liquid chromatography. Stability was defined as the retention of at least 90% of the initial concentration.

RESULTS:

At least 99% of the initial moxifloxacin remained throughout the 90-day study period in both preparations. There were no detectable changes in color, odor, taste, and pH and no visible microbial growth in any sample.

CONCLUSION:

Extemporaneously compounded suspensions of moxifloxacin 20 mg/mL in a 1:1 mixture of Ora-Plus and Ora-Sweet or Ora-Sweet SF were stable for at least 90 days when stored in 2-oz amber plastic bottles at room temperature.

PMID:
19299374
[PubMed - indexed for MEDLINE]
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