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Bioorg Med Chem Lett. 2009 Apr 15;19(8):2203-5. doi: 10.1016/j.bmcl.2009.02.101. Epub 2009 Feb 28.

Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.

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  • 1Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy.


A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.

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