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N Engl J Med. 2009 Mar 26;360(13):1310-9. doi: 10.1056/NEJMoa0810696. Epub 2009 Mar 18.

Mortality results from a randomized prostate-cancer screening trial.

Collaborators (783)

Berg CD, Gohagan JK, Prorok PC, Hsing AW, Lacey JV Jr, Purdue M, Hayes RB, Simpson NK, Cumberlin R, Rossi S, Zhu C, Huang WY, Marquez G, Browne JE, Hoffman S, Coleman DM, Jackson C, Lange E, McMillan D, Papadopoulos E, Sylver-Foust D, Sullivan D, Brown M, Gaegler J, Gray L, Greenwald P, Fraumeni JF Jr, Fagerstrom RM, Hu P, Izmirlian G, Levin DL, Pinsky P, Xu JL, Kreimer A, Marcus PM, Subar AF, Black A, Hartge P, Hoover RN, Ziegler RG, Costlow R, Laine AF, Miller AB, Pearson D, van Nagell JR, Stallings FL, Miller DS, Kramer BS, Chia D, Dry S, Seligson D, Terasaki P, Reiss J, Tze S, Acalinovich A, Besada S, Chan H, Cheung-Lau G, Corbett S, Durongwong P, Eeva M, Folayan L, Gruebel B, Habeeb O, Huynh K, Kanegai C, Kim H, Kim S, Ko A, Kohlmeier S, Lamb C, Lu M, Martin J, Maynard S, Noravian F, Schirrippa O, Padilla G, Rumbin A, Shevlin L, Ty R, Wang Q, Wong J, Xu S, Yu H, Koci J, Kopp W, Rager H, Smith C, Roser D, Cahill J, O'Brien B, Gardner S, Carrick D, Yurgalevitch S, Dunn M, Bailey C, Bodenstein Y, Burr P, Caughman C, Cutrin J, Eisen J, Frias A, Glashofer S, Hurtmullen K, Kavounis K, Ke P, Khanani F, Laimon B, Mechanic L, Menacker F, Mesnard M, Nichaman L, Novey S, Palace C, Peace S, Pettit K, Pratt S, Ragard L, Rosenbaum J, Sanchez D, Schuman S, Steward M, Waterman MB, Umbel K, Ferrantello D, Hasson MA, Bridgeman B, Martinusen E, Sabastianelli M, Miller A, Menacker F, Miedzinski M, Miesko L, Lease C, Rinehart M, Agamir M, Awatramani K, Barbee J, Barlow WC, Beach D, Bradley B, Brenner K, Butler L, Bristor J, Caughman C, Chanapatna R, Cranson L, Desir J, Donegan K, Fleming J, Florczyk M, Galyon J, Gordon C, Han C, Havel B, Hendricks A, Hickman D, Ho M, Jackson E, Kahane DC, Khan A, Laio M, Lee A, Lott B, Lucas-Mudd D, Moore D, Morgan A, Neagu G, Ohan P, Revzin M, Rychlec J, Samiel R, Siford E, Simons D, Smith M, Swei L, Theodorou E, Vakhlis A, Walsh JH, Wenzel B, Whitlock M, Williamson S, Wu M, Yang CL, Yoda S, Williamson S, Wu M, Myers MH, Young PA, Lewis DA, Francis RW Jr, Saunders LA, Signes C, Scheck S, Lake W Jr, Riley T, Austin J, Erwin DE, Flynn D, Mabie JE, Clapp JD, Moore MR, Xu F, Jones GC, Rathmell JM, Williams CR, Young M, Goodman A, Hickey TP, Commins JM, Wright P, Shaul SK, Crawford ED, Ogden SL, Tenorio S, Fyles P, Golz D, Hommel S, McCormick D, Pashleigh G, Slimak N, Turner N, Ayodeji NG, Josse D, McAfee J, Meskimen E, Pennington J, Suchey W, Ali-Ahmadi M, Barnett AW, Brothers J, Chronister ND, Cipolla D, Crawford R, Chun S, Gebhart K, Hunter H, Hernandez J, Patel K, Poage W, Pozzetta M, Simms S, Swingler J, Taylor C, Turner M, Wallack A, Curtis K, Pierce D, Borrego PV, Rundus C, Bonde E, Gamito E, Pretzel S, Dahmer J, Deines T, Geske M, Holladay M, Jackson H, Jordan T, Ordonez E, Beechum T, Crawford M, Dittmer K, Donohue A, Garcia F, Giese S, Kleinfield A, Kleinman M, Moss W, Motomiya K, Murken R, Neel D, Razook C, Shoaga A, Thompson A, Vargas S, Lynch D, O'Driscoll M, Townsend R, Stamm E, Drose J, Davidson S, Ahnen D, Levine J, Murchison W, Steinberg S, Gelmann EP, Isaacs C, McGuire C, Trocky N, Bourdeau C, Ke P, Martino L, Apostolides I, Elbon-Copp C, Klemm K, Lippman C, Klotz C, McLaurin T, Williams T, Ginyard J, Cantrell S, Marsh G, Tran A, Wray C, Yondonsambu B, Taddeo C, Bennett K, Bowen T, English K, Seaton K, Hammond T, Ford M, Newman K, Kren M, English N, McKenzie D, Yokochi LA, Gilbert F, Curb D, Kessel B, Navin J, Petrovich H, Shambaugh V, Tabrah F, Waitzfelder B, Willcox B, Jenkins V, Chasnoff R, Vander Does J, Martin J, Ideta B, Stryker K, Batangan E, Dolan L, Horton K, Taylor K, Tokumine T, Troyer R, Barrow S, Hayashida S, Commander S, Turner L, Hino G, Nakano E, Johnson M, Villaruz L, Chung A, Huynh W, Hickey N, Calulot M, Chun V, Lewis C, Morfit J, Tani J, Banggo K, Brunst A, Francis W, Grove L, Holderbaum B, Kinney K, O'Sullivan T, Rowan-Lau P, Bow K, Shiratori H, Tsukamoto J, Hodges H, Hyun S, Kuiee J, Lucente L, Oshiro P, Shota K, Kvale PA, Demers R, Fogel R, Rutt W, Bresalier RS, Johnson CC, Lamerato L, Broski K, Ford ME, LaFata JE, McCarthy B, Ward R, Andrews T, Day M, Flickinger LM, Hantz T, Talley D, Wilson D, Blount A, Tammemagi CM, Barr C, Hall T, Haykus W, Stanifer S, Baker P, Montague R, Day C, Nanovski A, Hill C, Boles T, Witherspoon A, Banks G, Green K, Bernardin K, Kozlowski P, Wells J, Salisbury H, Shepard A, McKeeman J, Jeffery T, Castor C, Boswell M, Gardner M, Hooker C, Maddy N, Morris J, Mototolea D, Berlicz J, Bonds T, Fountain S, Williams M, Djuric B, Szabo N, Cross C, Jagger F, Johnson A, McCarver L, Scharbonneau M, Thomas V, Norwood M, Mobley M, Kokko S, Doute D, Ciccoretti K, Wright KW, Emmer D, Shabazz P, Leyson-Fiel A, Pratt K, Bailey M, Alexander T, Kok JL, Church TR, Mandel J, Oken MM, Engelhard D, Cordes J, Geisser M, Watt G, Bradley P, Hansen C, Kokubu J, Lee R, Palmquist K, Sigal B, Barnes T, Fleishhacker M, Grengs J, Hebner S, Lewis M, Mendez A, Miller D, Nielsen J, Theis L, Ronan R, Rice M, DesMarais D, Mongin S, Silverman G, Strahan F, Portnov N, Sandley N, Vuong S, Zirbes A, Fredrickson A, Hoffbeck R, Murzyn R, Woodside J, Beckmann P, Boldt M, Jurjans L, Swenson S, Terrien S, Fisher J, Breer S, Collins S, Manuel J, Matous L, Muller C, Olsson P, Peterson S, Steele ML, Tonnell S, Halverson J, Hanna M, Hathaway-Ott J, Harper B, Hunter H, Lindall-Hawkins J, Longen C, Nickelson S, Overby D, Rodier M, Smith B, Weiner V, Haselhuhn C, Heath D, Julin E, Naslund LL, Skytta C, Warren D, Clement M, Michels N, Swavely D, Sitarz J, Thomas J, Steinberg C, Sielaff T, Watry M, Fraki S, Burrell J, Sandell L, Andriole GL, Lowery AA, Charlton E, Desai A, Gardner V, Stanczak D, Taylor K, Freesmeier E, Civitelli K, Ehrhard K, Nieters P, Hilke C, Phillips K, Robinson W, Wehde M, Branam C, Freesmeier K, Kane C, Murphey S, Royal D, Scire J, Bickford K, Fleming E, Goforth J, Graham D, Montani J, Naughton K, Palumbo B, Sicard-Su J, Blanke R, Cashel P, DeFord K, Liddy K, Lieberoff A, Nelson K, Reismeyer L, Ritter B, Robertson S, Standbrook S, Stilts D, Webb J, Garrett K, Laster S, Stolin C, Bullock A, Grubb R 3rd, Levitt R, Middleton M, McKnight R, James W, Weinstock L, Thyssen E, Fleshman J, Mutch M, Carter-Replog A, Mutch D, Gray D, Weissfeld JL, Hill L, Hakala T, Guido R, Fuhrman C, Overly W, Proctor JW, Schoen RE, Sulecki M, Trombetta M, Gahagan B, Bonk J, Yagjian M, Gitchel R, Sufka P, McDonough K, Carl K, Gongloff J, Karl T, Lucas C, Lytle L, Sibbet M, Weinstein J, Coopie B, Dyjak L, Johnson L, Kielty J, Landis G, Misko S, Oleson P, Ritman M, Clement L, Danvers A, Riley MA, Buys SS, Gren LH, Childs J, Andersen A, Bacon J, Bossi M, Briscoe L, Broschinsky M, Callahan B, Conner T, Ernst J, Fischer R, Gregersen J, Hamatake N, Hamatake C, Henrichsen A, lhler N, Jensen L, Jones K, Killian L, Liddle M, Lochner M, Monaco A, Morreal R, Nate A, Nolan K, Olson C, Park A, Ricks S, Sheltra S, Stewart A, Sturges L, Sullenger J, Taylor K, Toyn C, Van Stam E, Argyle N, Christensen J, Bennett S, Biggs J, Branson D, Bryson M, Childs B, Dalton C, Doi B, Doi J, Foss S, Gudgell P, Hicks L, Hsu P, LaMay D, Montalbo C, Newman L, Randall A, Thompson J, Schliep K, Stanfield K, Watson D, Newman L, Reese M, Whittaker B, Whittaker N, Wicklander E, Wolf J, Varner J, Bennett N, Bonoacci M, Harper A, Reay S, McFadden K, O'Toole K, Butcher T, Walker D, Richardson J, Hong H, Lund B, Rowley J, Tlachac J, VanRy J, Walker C, Hamilton B, Labasky R, Landau S, Middleton R, Stephenson R, Beck TM, Sturges L, Wohlers B, Berreth K, Roberts P, Carter P, Goodman D, Hagerman G, Hon T, Marshock J, Martin R, Burke L, Seifert AL, Reding D, Greenlee R, Hocking W, Lappe K, Multerer D, Fischer V, Heiting JC, Mueller C, Mathiesen-Viergutz K, Bohman K, Carey L, Vieth A, Aue K, Kriescher D, Miller C, Thums N, Wein S, Kofka K, Luttropp K, Mueller C, Dix B, Mueller L, Swensen K, Wachholz S, Kramer R, Bright B, Zahradka S, Fouad M, Oberman A, Partridge E, Urban D, Kiefe C, Shikany J, Higgins D, Thompson J, Johnson M, Moore A, Powell B, McCoy B, Oden C, Khatri R, Pike M, Buring JE, Alberts D, Carter HB, Chodak G, Hawk E, Malm H, Mayer RJ, Piantadosi S, Silvestri GA, Thompson IM, Westhoff CL, Kahn JP, Levin B, DeMets D, O'Fallon JR, Porter AT, Ashton MM, Black WC, Albertsen PC, Edmonson JH, Lawrence W, Fontana R, Rajput A, Miller AB, Eisenberger M, Jatoi I, Glatstein E, Welch HG.

Author information

  • 1Washington University School of Medicine, St. Louis, USA.

Erratum in

  • N Engl J Med. 2009 Apr 23;360(17):1797.

Abstract

BACKGROUND:

The effect of screening with prostate-specific-antigen (PSA) testing and digital rectal examination on the rate of death from prostate cancer is unknown. This is the first report from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial on prostate-cancer mortality.

METHODS:

From 1993 through 2001, we randomly assigned 76,693 men at 10 U.S. study centers to receive either annual screening (38,343 subjects) or usual care as the control (38,350 subjects). Men in the screening group were offered annual PSA testing for 6 years and digital rectal examination for 4 years. The subjects and health care providers received the results and decided on the type of follow-up evaluation. Usual care sometimes included screening, as some organizations have recommended. The numbers of all cancers and deaths and causes of death were ascertained.

RESULTS:

In the screening group, rates of compliance were 85% for PSA testing and 86% for digital rectal examination. Rates of screening in the control group increased from 40% in the first year to 52% in the sixth year for PSA testing and ranged from 41 to 46% for digital rectal examination. After 7 years of follow-up, the incidence of prostate cancer per 10,000 person-years was 116 (2820 cancers) in the screening group and 95 (2322 cancers) in the control group (rate ratio, 1.22; 95% confidence interval [CI], 1.16 to 1.29). The incidence of death per 10,000 person-years was 2.0 (50 deaths) in the screening group and 1.7 (44 deaths) in the control group (rate ratio, 1.13; 95% CI, 0.75 to 1.70). The data at 10 years were 67% complete and consistent with these overall findings.

CONCLUSIONS:

After 7 to 10 years of follow-up, the rate of death from prostate cancer was very low and did not differ significantly between the two study groups. (ClinicalTrials.gov number, NCT00002540.)

2009 Massachusetts Medical Society

Comment in

PMID:
19297565
[PubMed - indexed for MEDLINE]
PMCID:
PMC2944770
Free PMC Article

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