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Nat Prod Res. 2009;23(4):399-408. doi: 10.1080/14786410802230757.

Hypoglycaemic and antioxidant activities of Ficus racemosa Linn. fruits.

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  • 1Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh. ismet0103@yahoo.com

Abstract

The effects of Ficus racemosa Linn. fruit extract and fraction on fasting serum glucose levels of normal, type 1 and type 2 diabetic model rats are presented. The aqueous 80% EtOH extract and its water soluble fraction of F. racemosa fruit did not show any serum glucose lowering effect on non-diabetic and type 2 diabetic rats at the fasting condition, whereas the extract showed significant hypoglycaemic effect on the type 1 diabetic model rats. Both the extract and fraction were consistently active in both non-diabetic and types 1 and 2 diabetic model rats when fed simultaneously with glucose load. On the contrary, they were ineffective in lowering blood glucose levels when fed 30 min prior to glucose load. The 1-BuOH soluble part of the ethanol extract exhibited significant antioxidant activity in DPPH free radical scavenging assay. 3-O-(E)-Caffeoyl quinate (1) was isolated for the first time from this plant, which also showed significant antioxidant activity.

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