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    World J Gastroenterol. 2009 Mar 21;15(11):1346-52.

    Curcumin suppresses PPARdelta expression and related genes in HT-29 cells.

    Wang JB, Qi LL, Zheng SD, Wang HZ, Wu TX.

    Source

    Department of Chemistry, College of Science, Zhejiang University, Hanzhou 310027, Zhejiang Province, China.

    Abstract

    AIM:

    To investigate the effects of curcumin on the expression of peroxisome proliferator-activated receptordelta (PPARdelta) and related genes in HT-29 cells.

    METHODS:

    HT-29 cells were treated with curcumin (0-80 micromol/L) for 24 h. The effects of curcumin on the morphology of HT-29 cells were studied by Hoechst 33342 staining. The activity of caspase-3 was determined using DEVD-pNA as substrate. The levels of peroxisome PPARdelta, 14-3-3epsilon and vascular endothelial growth factor (VEGF) in HT-29 cells were determined by Western blotting analysis and their mRNA expression was determined by real-time quantitative RT-PCR.

    RESULTS:

    Treatment with 10-80 micromol/L curcumin induced typical features of apoptosis and activated the caspase-3 in HT-29 cells. The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.

    CONCLUSION:

    Curcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.

    PMID:
    19294764
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2658832
    Free PMC Article

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