Herpes zoster keratouveitis and inflammatory ocular hypertension 8 years after varicella vaccination

Ocul Immunol Inflamm. 2009 Jan-Feb;17(1):33-5. doi: 10.1080/09273940802491892.

Abstract

More than 8 years after varicella vaccination, a healthy 16 year-old boy presented with keratouveitis, severe inflammatory glaucoma in his left eye, and Hutchinson's sign. He was treated with systemic acyclovir, topical steroids, cycloplegics, and glaucoma medications for a full recovery two months after presentation. It is unclear whether the source of herpes zoster which reactivated in this patient represents wild type virus or his previous vaccine strain. Herpes zoster ophthalmicus is very rare in the pediatric population after varicella vaccination but can cause severe inflammatory glaucoma that requires aggressive therapy.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / therapeutic use
  • Adolescent
  • Antihypertensive Agents / therapeutic use
  • Chickenpox Vaccine / adverse effects*
  • Drug Therapy, Combination
  • Glucocorticoids / therapeutic use
  • Herpes Zoster Ophthalmicus / diagnosis
  • Herpes Zoster Ophthalmicus / drug therapy
  • Herpes Zoster Ophthalmicus / virology*
  • Herpesvirus 3, Human / physiology
  • Humans
  • Intraocular Pressure
  • Keratitis, Herpetic / diagnosis
  • Keratitis, Herpetic / drug therapy
  • Keratitis, Herpetic / virology*
  • Male
  • Mydriatics / therapeutic use
  • Ocular Hypertension / diagnosis
  • Ocular Hypertension / drug therapy
  • Ocular Hypertension / virology*
  • Uveitis, Anterior / diagnosis
  • Uveitis, Anterior / drug therapy
  • Uveitis, Anterior / virology*
  • Vaccination
  • Virus Activation / physiology

Substances

  • Antihypertensive Agents
  • Chickenpox Vaccine
  • Glucocorticoids
  • Mydriatics
  • Acyclovir