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Dement Geriatr Cogn Disord. 2009;27(4):344-52. doi: 10.1159/000209212. Epub 2009 Mar 17.

Agreement in cognitive and clinical assessments in Alzheimer's disease.

Author information

  • 1Departments of Neurology, Biostatistics, Bioinformatics and Biomathematics, and Psychiatry, Georgetown University School of Medicine, Washington, D.C. 20057, USA. ret7@georgetown.edu

Abstract

AIMS:

To estimate agreement among scores on three common assessments of cognitive function.

METHOD:

Baseline responses on the Alzheimer's Disease Assessment Scale - Cognitive, Clinical Dementia Rating, and the Mini-Mental State Examination were obtained from two clinical trials (n = 138 and n = 351). A graphical method of examining agreement, the means-difference or Bland-Altman plot, was followed by Levene's test of the equality of variance corrected for multiple comparison within each sample.

RESULTS:

70-78% of variability was shared by one factor, suggesting that all three instruments reflect cognitive impairment. However, agreement among tests was significantly worse for individuals with greater-than-average, relative to individuals with less-than-average, cognitive impairment.

CONCLUSIONS:

Worse agreement between tests, as a function of increasing cognitive impairment, implies that interpretation of these tests and selection of coprimary cognitive impairment outcomes may depend on impairment level.

PMID:
19293567
[PubMed - indexed for MEDLINE]
PMCID:
PMC2820316
Free PMC Article

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