J Am Acad Dermatol. 2009 Apr;60(4):700-3.

Penicillamine-induced elastosis of the mucosal lip.

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Department of Internal Medicine, University of Utah Hospitals and Clinics, Salt Lake City, Utah, USA.

Abstract

Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy"" or "bramble-bush"" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.

PMID:: 19293020; [PubMed - indexed for MEDLINE]

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