Ugeskr Laeger. 2009 Mar 9;171(11):881-4.

[Aliskiren combined with losartan in type 2-diabetes and nephropathy - secondary publication].

[Article in Danish]

Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK.

Source

Aarhus Universitet, Det Sundhedsvidenskabelige Fakultet, Steno Diabetes Center. hhparving@dadlnet.dk

Abstract

We evaluated the renoprotective effects of adding aliskiren to treatment with losartan in hypertensive patients with type 2 diabetes and nephropathy. A total of 599 patients were randomized to six months of treatment with placebo or aliskiren in addition to losartan 100 mg and optimal antihypertensive therapy. The primary outcome was a reduction in the urinary albumin-creatinine ratio. Aliskiren 300 mg daily reduced the mean urinary albumin-creatinine ratio by 20% (p < 0.001) compared with placebo. The number of adverse events was similar between groups. Aliskiren is renoprotective independently of its blood pressure lowering effect.

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N Engl J Med. 2008 Jun 5;358(23):2433-46.

PMID:: 19291865; [PubMed]

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Aliskiren combined with losartan in type 2 diabetes and nephropathy. [N Engl J Med. 2008]
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[Aliskiren combined with losartan in type 2-diabetes and nephropathy - secondary publication].

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