World J Gastroenterol. 2009 Mar 14;15(10):1168-77.

In vitro and in vivo models of acute alcohol exposure.

Source

Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States. angela.dolganiuc@umassmed.edu

Abstract

Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.

PMID:: 19291816; [PubMed - indexed for MEDLINE]
PMCID:: PMC2658858

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Alcoholism - MedlinePlus Health Information

Molecular Biology Databases

ETHANOL - HSDB

Supplemental Content

Icon for Baishideng Publishing Group Co., Limited

Save items

Related citations in PubMed

Review Neurobiology of alcohol abuse. [Trends Pharmacol Sci. 1992]
Review Neurobiology of alcohol abuse.
Samson HH, Harris RA. Trends Pharmacol Sci. 1992 May; 13(5):206-11.
Review Advances in nonhuman primate alcohol abuse and alcoholism research. [Pharmacol Ther. 2003]
Review Advances in nonhuman primate alcohol abuse and alcoholism research.
Grant KA, Bennett AJ. Pharmacol Ther. 2003 Dec; 100(3):235-55.
Review Alcohol abuse and acute lung injury: epidemiology and pathophysiology of a recently recognized association. [J Investig Med. 2005]
Review Alcohol abuse and acute lung injury: epidemiology and pathophysiology of a recently recognized association.
Guidot DM, Hart CM. J Investig Med. 2005 Jul; 53(5):235-45.
Review Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models? [J Physiol Pharmacol. 2003]
Review Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?
Siegmund S, Spanagel R, Singer MV. J Physiol Pharmacol. 2003 Dec; 54 Suppl 4:191-207.
Patterns of ethanol intake in preadolescent, adolescent, and adult Wistar rats under acquisition, maintenance, and relapse-like conditions. [Alcohol Clin Exp Res. 2009]
Patterns of ethanol intake in preadolescent, adolescent, and adult Wistar rats under acquisition, maintenance, and relapse-like conditions.
García-Burgos D, González F, Manrique T, Gallo M. Alcohol Clin Exp Res. 2009 Apr; 33(4):722-8. Epub 2009 Jan 22.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Cellular and mitochondrial effects of alcohol consumption. [Int J Environ Res Public Healt...]
Review Cellular and mitochondrial effects of alcohol consumption.
Manzo-Avalos S, Saavedra-Molina A. Int J Environ Res Public Health. 2010 Dec; 7(12):4281-304. Epub 2010 Dec 21.
Review Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. [Alcohol Clin Exp Res. 2010]
Review Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.
D'Souza El-Guindy NB, Kovacs EJ, De Witte P, Spies C, Littleton JM, de Villiers WJ, Lott AJ, Plackett TP, Lanzke N, Meadows GG. Alcohol Clin Exp Res. 2010 Sep 1; 34(9):1489-511. Epub 2010 Jun 25.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

In vitro and in vivo models of acute alcohol exposure.
In vitro and in vivo models of acute alcohol exposure.
World J Gastroenterol. 2009 Mar 14 ;15(10):1168-77.

PubMed
Increased intestinal permeability and tight junction alterations in nonalcoholic...
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
Hepatology. 2009 Jun ;49(6):1877-87.

PubMed
Hypertrophic scarring of the neck following ablative fractional carbon dioxide l...
Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing.
Lasers Surg Med. 2009 Mar ;41(3):185-8.

PubMed
Proteomic analysis for process development and control of therapeutic protein se...
Proteomic analysis for process development and control of therapeutic protein separation from human plasma.
Electrophoresis. 2009 Apr ;30(7):1185-93.

PubMed
Human self-protein CD8+ T-cell epitopes are both positively and negatively selec...
Human self-protein CD8+ T-cell epitopes are both positively and negatively selected.
Eur J Immunol. 2009 Apr ;39(4):1056-65.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

In vitro and in vivo models of acute alcohol exposure.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information